Journal
BIOMATERIALS
Volume 26, Issue 32, Pages 6296-6304Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2005.04.018
Keywords
polylactide; hydroxyapatite; composite; mechanical properties; biocompatibility; cell culture
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In order to improve the bonding between hydroxyapatite (HAP) particles and poly(t-lactide) (PLLA), and hence to increase mechanical properties of the PLLA/HAP composite as potential bone substitute material. the HAP nano-particles were surface-grafted with PLLA and further blended with PLLA. The structure and properties of the composites were subsequently investigated by the mechanical property testing, the differential scanning calorimeter measurements (DSC), the scanning electron microscopy (SEM), the polarized optical microscopy (POM), and the cell culture. The PLLA molecules grafted oil (lie HAP surfaces, as inter-tying molecules, played an important role in improving the adhesive strength between the particles and the polymer matrix. At a low content (similar to 4 wt%) of surface grafted-HAP (g-HAP), the PLLA/g-HAP nano-composites exhibited higher bending strength and impact energy than the pristine PLLA, and at a higher g-HAP content (e.g., 20wt%), the modulus was remarkably increased, It implied that PLLA could be strengthened as well as toughened by g-HAP nano-particles. The results of biocompatibility test showed that the g-HAP existing in the PLLA composite facilitated both adhesion and proliferation of chondrocytes on the PLLA, g-HAP composite film, (c) 2005 Elsevier Ltd. All rights reserved.
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