Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 52, Issue 11, Pages 4194-4197Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01337-07
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Funding
- Ministry of Health, Labor and Welfare of Japan [H18-Shinko-011, H19-Shinko-011, H20-Shinko-011]
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A novel gene, bla(KHM-1), encoding a metallo-beta-lactamase, KHM-1, was cloned from a clinical isolate of Citrobacter freundii resistant to most beta-lactam antibiotics. Escherichia coli expressing bla(KHM-1) was resistant to all broad-spectrum beta-lactams except for monobactams and showed reduced susceptibility to carbapenems. Recombinant KHM-1 exhibited EDTA-inhibitable hydrolytic activity against most beta-lactams, with an overall preference for cephalosporins.
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