Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 1, Pages 264-266Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00258-08
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Funding
- Cubist Pharmaceuticals
- National Institute of Allergy and Infectious Disease [AI069087]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI069087] Funding Source: NIH RePORTER
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We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
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