4.7 Article

The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 52, Issue 9, Pages 3427-3429

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00493-08

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Funding

  1. U. S. Department of Veterans Affairs
  2. National Institute of Allergy and Infectious Diseases [AI45626]

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The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.

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