Journal
NATURE GENETICS
Volume 37, Issue 11, Pages 1210-1212Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1652
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Stratifin (Sfn, also called 14-3-3 sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice.
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