4.7 Article

Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 52, Issue 4, Pages 1559-1563

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01052-07

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Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-beta-naphthylamide (PA beta N) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.

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