Activities of Daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus aend its stable small-colony variant in human monocyte-derived macrophages and in broth

We investigated the antistaphylococcal activities of daptomycin,gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.