Journal
JOURNAL OF NEUROTRAUMA
Volume 22, Issue 11, Pages 1282-1293Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2005.22.1282
Keywords
canine; olfactory glial cell; tissue culture; transplantation
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Intraspinal transplantation of olfactory glial cells (OGC) has produced well-defined beneficial effects in experimental rodent models of spinal cord injury (SCI) and therefore has considerable promise as a treatment for severe SCI in human patients. In this study, we used clinical canine cases of severe SCI to determine whether derivation and transplantation of OGC from an autologous source was feasible. From the nerve fiber layer of a single olfactory bulb, we were able to generate 5 X 106 cells from each patient within 3 weeks. Of this population, 72% were p75(+) OGC, 20% were meningeal cells, and the remainder mainly astrocytes. Intraspinal. transplantation was not associated with any observable long- or short-term complications.
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