4.7 Article

Antimicrobial Activities of Jadomycin B and Structurally Related Analogues

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 3, Pages 1245-1247

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00801-08

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Funding

  1. Atlantic chapter of the Canadian Breast Cancer Foundation
  2. Dalhousie University Pharmacy Endowment Fund
  3. Canadian Institutes of Health Research
  4. RxD
  5. National Research Council of Canada Institute for Marine Biosciences

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Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.

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