Journal
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
Volume 10, Issue 6, Pages 535-539Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
DOI: 10.1007/BF02932290
Keywords
2-keto-3-deoxy-D-gluconate kinase; Thermoplasma acidophilum; glycolysis; non-phosphorylated Enter-Doudoroff pathway; phosphoprotein; Euryarchaeota
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The thermoacidophilic archaeon Thermoplasma acidophilum has long been known to utilize D-glucose via the non-phosphorylated Entner-Doudoroff (nED) pathway. We now report the identification of a gene encoding 2-keto-3-deoxy-D-gluconate (KDG) kinase. The discovery of this gene implies the presence of a glycolysis pathway, other than the nED pathway. It was found that Ta0122 in the T. acidophilum genome corresponded to KDG kinase. This enzyme shares no similarity with known KDG kinases, and belongs to a novel class of sugar kinases. Of the five sugars tested only KDG was utilized as a substrate.
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