Journal
LEUKEMIA & LYMPHOMA
Volume 46, Issue 11, Pages 1531-1544Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190500215076
Keywords
mesenchymal stem cell; differentiation; plasticity; hemopoietic stem cell transplantation; immunomodulation; gene transfer
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Human mesenchymal stem cells (MSCs) contribute to the regeneration of mesenchymal tissues, and are essential in providing support for the growth and differentiation of primitive hemopoietic cells within the bone marrow micro-environment. Techniques are now available to isolate human MSCs and manipulate their expansion in vitro under defined culture conditions without change of phenotype or loss of function. Mesenchymal stem cells have generated a great deal of interest in many clinical settings, including that of regenerative medicine, immune modulation and tissue engineering. Studies have already demonstrated the feasibility of transplanted MSCs providing crucial new cellular therapy. In this review, many aspects of the MSC will be discussed, with the main focus being on clinical studies that describe the potential of MSCs to treat patients with hematological malignancies who are undergoing chemotherapy and/or radiotherapy.
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