Journal
INFECTION AND IMMUNITY
Volume 73, Issue 11, Pages 7759-7764Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.11.7759-7764.2005
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Funding
- NIAID NIH HHS [R01 AI040488, AI-40488, R01 AI045707, AI-45707] Funding Source: Medline
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In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44(hi) CD62 ligand(lo) (CD62L(lo)) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naive phenotype (CD44(lo) CD62L(hi)) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.
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