Journal
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
Volume 32, Issue 4, Pages 540-545Publisher
CANADIAN J NEUROL SCI INC
DOI: 10.1017/S0317167100004583
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Objective: To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary. Methods: The surgically removed tumor was studied by histology, immunohistochemistry and transmission electron microscopy. Results: An aggressive invasive sellar tumor removed by repeated surgeries from a 43-year-old woman with pituitary related Cushing's disease was classified as a Crooke's cell adenoma of the pituitary. The application of several cell proliferation markers confirmed the aggressive nature of the tumor. Conclusions: The investigation of the present case provides additional evidence that pituitary Crooke's cell adenomas may possess aggressive behavior.
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