Journal
JOURNAL OF PEDIATRICS
Volume 147, Issue 5, Pages 632-639Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2005.06.037
Keywords
-
Categories
Ask authors/readers for more resources
Objective To determine the efficacy of iron and zinc supplementation on behavior ratings of lead-exposed children. Study design In this double-blind, randomized trial, 602 first-grade children received 30 mg ferrous fumarate, 30 mg zinc oxide, both, or placebo daily for 6 months. Lead, iron, and zinc status were determined at baseline and follow-up. Parents and teachers provided ratings of child behavior using the Conners Rating Scales. Results The baseline mean (SD) blood lead concentration was 11.5 (6.1) mu g/dL, with 51% of children >= 10 mu g/dL. The prevalence of attention deficit hyperactivity disorder, estimated by combined parent and teacher ratings, was 6%. At follow-up, parent ratings of oppositional, hyperactive, cognitive problems, and attention deficit hyperactivity disorder decreased by 1.5, 1.2, 2.5, and 3.4 points, respectively (P < .05). Teacher ratings of hyperactivity increased by 1.1 points (P = .008), and the mean cognitive problem score declined by 0.7 points (P = .038). There were no treatment effects on mean change in scores, but children receiving any zinc had a higher likelihood of no longer receiving clinically-significant teacher ratings of oppositional behaviors. Conclusions This regimen of supplementation did not result in consistent improvements in ratings of behavior in lead-exposed children over 6 months.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available