Journal
EUROPEAN JOURNAL OF CANCER
Volume 41, Issue 16, Pages 2577-2586Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2005.08.007
Keywords
transcription; DNA damage; drug resistance; DNA repair; cisplatin
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Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin. (c) 2005 Elsevier Ltd. All rights reserved.
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