Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 99, Issue 3, Pages 211-213Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.FMJ05002X4
Keywords
T-type Ca2+ channel; gene transcription; neuron-restrictive silencer factor; repressor
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Expression of T-type Ca2+ current in the ventricle varies during development and in cardiac diseases. The alteration in quantity of two isoforms of T-type Ca-2+ channel genes in the heart, CACNA1G and CACNA1H, contributes to the changes of T-type Ca-2+ channel activity. However, the precise mechanisms governing the transcription of T-type Ca2+ channel genes remain largely unknown. In this review, we briefly describe our recent finding that a transcriptional repressor named neuron-restrictive silencer factor is a potent regulator of T-type Ca2+ channel gene expression.
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