Journal
NATURE NEUROSCIENCE
Volume 8, Issue 11, Pages 1450-1457Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1583
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Funding
- NCRR NIH HHS [M01-RR00102] Funding Source: Medline
- NIDA NIH HHS [K05-DA00049, P60-DA05130] Funding Source: Medline
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Genetic variation may partially underlie complex personality and physiological traits-such as impulsivity, risk taking and stress responsivity-as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.
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