Journal
JOURNAL OF ANTIBIOTICS
Volume 58, Issue 11, Pages 695-703Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2005.95
Keywords
stemphones; imipenem potentiator; methicillin-resistant Staphylococcus aureus; MRSA; fungal metabolite; tetracyclic quinone
Ask authors/readers for more resources
A fungal strain FKI-2136 identified as genus Aspergillus was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 told by decreasing MIC value of imipenem from 16 mu g/ml to 0.03 mu g/ml.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available