Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 168, Issue 1-2, Pages 21-33Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.06.016
Keywords
Toll-like receptor 2; TNF; brain; Streptococcus pneumoniae; meningitis
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TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of TLR2 and of the comolecules CD14, MD-2, TLR1/6 strongly increased and colocalized with TNF in CD45-positive infiltrating cells in the ventricles, corpus callosum and the meninges. TNF gene and protein expression was stronger in TLR2(-/-) than wt brains and associated with increased I kappa B expression suggesting that TLR2 is controlling inflammation via TNF regulation. (C) 2005 Elsevier B.V. All rights reserved.
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