Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 15, Issue 8, Pages 302-308Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2005.09.005
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Funding
- NCRR NIH HHS [RR07002] Funding Source: Medline
- NHLBI NIH HHS [HL074945, P01 HL56091, P01 HL65608, R01 HL63706-04, R01 HL074061] Funding Source: Medline
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Weibel-Palade bodies (WPBs) are endothelial granules that store von Willebrand factor (VWF), P-selectin, and other vascular modulators. Endothelial cells secrete WPBs in response to vascular injury, releasing VWF, which triggers platelet rolling, and externalizing P-selectin, which activates leukocyte trafficking. Endothelial exocytosis is one of the earliest responses to vascular damage and plays a pivotal role in thrombosis and inflammation. This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs.
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