Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 25, Issue 6, Pages 541-550Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-005-8217-6
Keywords
NF-kappa B; IKK; cell death; cancer therapy
Categories
Funding
- NCI NIH HHS [CA 76188] Funding Source: Medline
- NIAID NIH HHS [AI 43477] Funding Source: Medline
- NIEHS NIH HHS [ES 04151] Funding Source: Medline
Ask authors/readers for more resources
The most extensively studied function of NF-kappa B is its ability to promote cell survival through induction of target genes, whose products inhibit various aspects of the apoptotic machinery in both normal and malignant cells. Recent studies, however, indicate that NF-kappa B activation can also suppress programmed necrosis through induction of genes encoding anti-oxidant proteins. Since tumor cells often use NF-kappa B pathway as a shield to escape the killing of conventional anti-cancer therapies, intervention of IKK/NF-kappa B signaling would be a promising option to improve the efficacy of cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available