Journal
NATURE BIOTECHNOLOGY
Volume 23, Issue 11, Pages 1399-1405Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1161
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Funding
- NCI NIH HHS [P01 CA62220] Funding Source: Medline
- NIAID NIH HHS [R01 AI34039] Funding Source: Medline
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Inhibition of gene expression through RNA interference (RNAi) is emerging as a powerful experimental tool for gene function and target validation studies. The potential uses of this technology seem unlimited, extending to the prevention and therapy of human diseases. However, recent work demonstrating that there are unanticipated, different nonspecific effects associated with the use of small interfering RNAs in mammals has raised concerns about the safe use of RNAi in vivo. These nonspecific effects include activation of the immune system, potentially harming the individual. The application of screening assays for nonspecific activation of both innate and acquired immunity will be necessary for further development of RNAi as a therapeutic tool.
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