Journal
EXPERIMENTAL PHYSIOLOGY
Volume 90, Issue 6, Pages 791-797Publisher
BLACKWELL PUBLISHING
DOI: 10.1113/expphysiol.2005.030924
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Funding
- Wellcome Trust Funding Source: Medline
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Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.
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