Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 289, Issue 5, Pages L685-L695Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00247.2005
Keywords
acute lung injury; acute respiratory distress syndrome; alveolar epithelium; alveoli lung
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Funding
- NHLBI NIH HHS [HL-48129, HL-65161] Funding Source: Medline
- PHS HHS [P01-71643] Funding Source: Medline
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The mechanisms of pulmonary edema resolution are different from those regulating edema formation. Absorption of excess alveolar fluid is an active process that involves vectorial transport of Na+ out of alveolar air spaces with water following the Na+ osmotic gradient. Active Na+ transport across the alveolar epithelium is regulated via apical Na+ and chloride channels and basolateral Na-K-ATPase in normal and injured lungs. During lung injury, mechanisms regulating alveolar fluid reabsorption are inhibited by yet unclear pathways and can be upregulated by pharmacological means. Better understanding of the mechanisms that regulate edema clearance may lead to therapeutic interventions to improve the ability of lungs to clear fluid, which is of clinical significance.
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