Journal
INFECTION AND IMMUNITY
Volume 73, Issue 11, Pages 7772-7774Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.11.7772-7774.2005
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Funding
- NIAID NIH HHS [R37 AI47923, R37 AI047923] Funding Source: Medline
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In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1PF in vegetations, organs, and blood, despite being inoculated in greater numbers. These results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis.
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