Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 12, Issue 11, Pages 1019-1020Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1006
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Herpesviruses encode a protease that is activated by homodimerization at high enzyme concentrations during lytic replication. The homodimer contains two active sites, which are distal from the dimer interface. Assignment of backbone NMR resonances and engineering of a redox switch show that two helices position a loop containing catalytic residues within each active site.
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