Journal
JOURNAL OF SEPARATION SCIENCE
Volume 28, Issue 17, Pages 2282-2287Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200500165
Keywords
1,1 '-bi-2-naphthol; chiral separation; molecular imprinting polymer; monolithic column; 5,5 ',6,6 ',7,7 ',8,8 '-octahydro-1,1 '-bi-2-naphthol
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Two molecular imprinting polymer (MIP) monolithic columns with (S)-(-)-1,1'-bi-2-naphthol and (R)-(+)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol as the templating molecules, respectively, have been prepared by in situ polymerization using 4-vinylpyridine and ethylene dimethacrylate as functional monomer and cross-linker, respectively. The columns with good flow-through properties were obtained by changing the molar ratio of the functional monomer and the template molecule. The effects of mobile-phase composition on separation of enantiomers were systematically investigated. The results indicate that hydrophobic interaction in aqueous solution and hydrogen-bonding interaction in ACN between the enantiomers and polymers could play important roles in the retention and resolution. The effects of chromatographic conditions, such as flow rate, column temperature, sample loading, on the enantioseparation were also studied. Further, these two MIP columns show a cross-reactivity.
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