4.6 Article

NKG2D in NK and T cell-mediated immunity

Journal

JOURNAL OF CLINICAL IMMUNOLOGY
Volume 25, Issue 6, Pages 534-540

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-005-8786-4

Keywords

NK cells; NKG2D; DAP10; RAE-1; MICA; autoimmunity; bone marrow transplantation; T cell

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One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gamma delta-TcR+ T cells and alpha beta-TcR+ CD8(+) T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

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