Journal
BIOINFORMATICS
Volume 21, Issue 21, Pages 3943-3950Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bti654
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The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.
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