Journal
EPILEPSY & BEHAVIOR
Volume 7, Issue 3, Pages 390-400Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2005.07.019
Keywords
dentate gyrus; hippocampus; inhibition; neuropeptide; calcium-binding protein; GABA; temporal lobe epilepsy
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Funding
- NINDS NIH HHS [R21 NS042346, NS042346] Funding Source: Medline
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Temporal lobe epilepsy is one of the most common forms of epilepsy. Numerous contributing factors and compensatory mechanisms have been associated with temporal lobe epilepsy. One feature found in both humans and animal models is sprouting of hippocampal principal cell axons, which suggests that axonal sprouting may be a general phenomenon associated with temporal lobe epilepsy. This article highlights the evidence showing that hippocampal GABAergic interneurons also undergo axonal sprouting in temporal lobe epilepsy. The caveats and unanswered questions associated with the current data and the potential physiological consequences of reorganizations in GABAergic circuits are discussed. Published by Elsevier Inc.
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