Journal
FASEB JOURNAL
Volume 19, Issue 13, Pages 1771-1777Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.04-3401hyp
Keywords
subthalamic nucleus; slow-wave sleep; burst-firing; basal ganglia
Categories
Funding
- NINDS NIH HHS [NS38715] Funding Source: Medline
Ask authors/readers for more resources
Information processing in the brain requires adequate background neuronal activity. As Parkinson's disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine-depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. Using agonists of dopamine receptors in the D1 and D2 families on rat brain slices, we show that dopamine receptors in these two families govern the firing pattern of neurons in the subthalamic nucleus, a crucial part of the basal ganglia. We propose a conceptual frame, based on specific properties of dopamine receptors, to account for the dominance of different background firing patterns in normal and dopamine-depleted states.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available