Journal
AUTOIMMUNITY REVIEWS
Volume 4, Issue 8, Pages 526-531Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2005.04.004
Keywords
autoimmunity; CD20; immunotherapy; mimotope; peptide; rituximab; vaccine
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This article reviews the role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases. Active immunotherapy is a more feasible way to control these chronic diseases. A peptide that mimics the CD20 epitope recognized by Rituximab is employed to stimulate the host immune response against CD20. (c) 2005 Elsevier B.V. All rights reserved.
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