Journal
AGEING RESEARCH REVIEWS
Volume 4, Issue 4, Pages 451-480Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2005.06.007
Keywords
dietary restriction; aging; demography; biodemography; microarray; gene expression
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Funding
- NIA NIH HHS [R01AG023166, T32AG000183] Funding Source: Medline
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Reduced nutrient availability (dietary restriction) extends lifespan in species as diverse as yeast, nematode worms, Daphnia, Drosophila, and mammals. Recent demographic experiments have shown that moderate nutrient manipulation in adult Drosophila affects current mortality rate in a completely reversible manner, which suggests that dietary restriction in Drosophila increases lifespan through a reduction of the current risk of death rather than a slowing of aging-related damage. When examined in the light of the new demographic data, age-dependent changes in gene expression in normal and diet-restricted flies can provide unique insight into the biological processes affected by aging and may help identify molecular pathways that regulate it. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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