Journal
NATURE MEDICINE
Volume 11, Issue 11, Pages 1244-1249Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1309
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Funding
- NCI NIH HHS [P01 CA 49542] Funding Source: Medline
- NHLBI NIH HHS [R01 HL55593] Funding Source: Medline
- NIAID NIH HHS [K08 AI052863-01] Funding Source: Medline
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Graft-versus-leukemia ( GVL) response after allogeneic bone marrow transplantation ( BMT) represents one of the most potent forms of immunotherapy against malignant diseases(1). Antigen-presenting cells ( APCs) are crucial for the induction of graft-versus-host disease ( GVHD)(2-6), the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.
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