Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 14, Issue 6, Pages 793-799Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520614666140521120811
Keywords
Allyl sulfides; apoptosis; carcinogenesis; cell cycle; Garlic; organosulfur compounds
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Funding
- State Key Development Program for Basic Research of China [2012CB517500]
- Program of the Shanghai Committee of Science and Technology [09140903500, 10411956300]
- National Natural Science Foundation of China [81070322, 81270491]
- 100 Talents Program of the Shanghai Board of Health [XBR2011007]
- National Health and Medical Research Council of Australia (NHMRC) [1053206, APP1047417]
- Cancer Council NSW grant [APP1070076]
- Career Development and Support Fellowship Future Research Leader Grant of the NSW Cancer Institute [08/FRL/1-04]
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Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
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