Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 13, Issue 7, Pages 1048-1056Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/18715206113139990130
Keywords
Natural products; PI3K/Akt; autophagy; cancer stem cell; stemness; cell death; anticancer drugs
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Funding
- Swedish Research Council
- Karolinska Institute
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The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a key regulator of authophagy. Natural products show anticancer activity and often induce apoptosis or autophagy. The crosstalk between these two types of cell death makes autophagy an interesting target since drugs targeting this process not only can induce cell death by inducing autophagy but can also sensitize cells to apoptosis. Autophagy is also a protective mechanism associated with increased resistance to chemotherapy. In this review, we discuss natural products known to induce autophagy cell death in cancer cells via the PI3K/Akt/mTOR pathway.
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