Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 13, Issue 7, Pages 971-978Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/18715206113139990119
Keywords
Akt; mTOR; apigenin; cancer
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Funding
- NIH [CA161181, CA104768]
- American Cancer Society, Illinois Division, Inc. [167567]
- Zell Foundation
- Rosenberg Fund
- H Foundation
- Northwestern University Skin Disease Research Center
- Cell Imaging Facility
- Robert H. Lurie Comprehensive Cancer Center
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Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin's inhibition of the PI3K/Akt/mTOR signaling pathways.
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