Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 13, Issue 7, Pages 1002-1013Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/18715206113139990078
Keywords
Indole compounds; PI3K; cancer therapy; NF-kappa B; Glucosinolates
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Funding
- NCI NIH HHS [R01 CA108535] Funding Source: Medline
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Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These natural compounds are also effective modulators of downstream transcription factor NF-kappa B signaling which might help explain their ability to inhibit invasion and angiogenesis, and the reversal of epithelial-to-mesenchymal transition (EMT) phenotype and drug resistance. Signaling through PI3K/Akt/mTOR and NF-kappa B pathway is increasingly being realized to play important role in EMT through the regulation of novel miRNAs which further validates the importance of this signaling network and its regulations by indole compounds. Here we will review the available literature on the modulation of PI3K/Akt/mTOR/NF-kappa B signaling by both parental I3C and DIM, as well as their analogs/derivatives, in an attempt to catalog their anticancer activity.
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