Journal
ENVIRONMENTAL HEALTH PERSPECTIVES
Volume 113, Issue 11, Pages 1638-1644Publisher
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.8111
Keywords
air pollution; birth weight; carbon monoxide; intrauterine growth retardation; maternal exposure; nitrogen dioxide; ozone; particulate matter
Funding
- NHLBI NIH HHS [5R01HL61768, R01 HL061768] Funding Source: Medline
- NIEHS NIH HHS [P01 ES011627, 5P01 ES009581, P30 ES007048, P01 ES009581, 5P01 ES011627, 5P30 ES07048] Funding Source: Medline
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Exposures to ambient air pollutants have been associated with adverse birth outcomes. We investigated the effects of air pollutants on birth weight mediated by reduced fetal growth among term infants who were born in California during 1975-1987 and who participated in the Children's Health Study. Birth certificates provided maternal reproductive history and residence location at birth. Sociodemographic factors and maternal smoking during pregnancy were collected by questionnaire. Monthly average air pollutant levels were interpolated from monitors to the ZIP code of maternal residence at childbirth. Results from linear mixed effects regression models showed that a 12-ppb increase in 24-hr ozone averaged over the entire pregnancy was associated with 47.2 g lower birth weight [95% confidence interval (CI), 27.4-67.0 g], and this association was most robust for exposures during the second and third trimesters. A 1.4-ppm difference in first-trimester carbon monoxide exposure was associated with 21.7 g lower birth weight (95% Cl, 1.1-42.3 g) and 20% increased risk of intrauterine growth retardation (95% Cl, 1.0-1.4). First-trimester CO and third-trimester O-3 exposures were associated with 20% increased risk of intrauterine growth retardation. A 20-mu g/m(3) difference in levels of particulate matter <= 10 mu m in aerodynamic diameter (PM10) during the third trimester was associated with a 21.7-g lower birth weight (95% Cl, 1.1-42.2 g), but this association was reduced and not significant after adjusting for O-3. In summary, O-3 exposure during the second and third trimesters and CO exposure during the first trimester were associated with reduced birth weight.
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