Journal
CHEMBIOCHEM
Volume 6, Issue 11, Pages 2005-2013Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200500168
Keywords
ab initio calculations; Eg5; inhibitors; kinesin; mitosis; spindle
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Human Eg5 is a mitotic kinesin that is essential for bipolar spindle formation and maintenance during mitosis. Recently, the discovery of compounds that inhibit Eg5 and cause mitotic arrest has attracted great interest, due to their potential use as the next generation of antimitotics. Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)thiones as selective and potent Eg5 inhibitors.
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