Journal
CURRENT PHARMACEUTICAL ANALYSIS
Volume 1, Issue 3, Pages 283-308Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157341205774597922
Keywords
fluoroquinolones; metabolites; chromatographic analyses; sample preparation; drugs; pharmaceuticals; biological samples
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Fluoroquinolones constitute a member of quinolone antibiotics, an expanding group of synthetic antibiotics, which are effective towards pathogens resistant to other antibacterials. They are broadly used for the treatment of several infections, both in human and veterinary medicine, due to their favourable kinetics and broad antibacterial activity. Herein recent advances in chromatographic methods for determination of fluoroquinolones and their metabolites are reviewed, focusing on sample pretreatment, chromatographic conditions, detection techniques, method validation and application to real samples. Results of published methods are comparatively presented and criticized.
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