Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 12, Issue 7, Pages 753-763Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187152012802650165
Keywords
Hepatocellular carcinoma (HCC); Hepatitis B virus (HBV); Hepatitis C virus (HCV); Alcoholic liver diseases; Non-alcoholic liver diseases; Bone marrow-derived stem cell; Matrix metalloproteinase (MMP); Tissue inhibitor of metalloproteinase (TIMP); Cancer invasion; Cancer metastasis; Cancer treatment; Anti-cancer agents
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Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedifferentiation of hepatoma cells. It introduces the reports on anti-cancer agents in the field of MMP science, and finally describes novel strategies for the early stages of HCC in relation to cancer stem cells.
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