Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 8, Issue 1, Pages 92-121Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187152008783330815
Keywords
glycopeptides; glyconanoparticles; tumour-associated carbohydrate antigens; glycoconjugates; anti-tumour vaccines
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This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential antitumour therapeutics will be considered.
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