Journal
EXPERIMENTAL BRAIN RESEARCH
Volume 167, Issue 1, Pages 136-140Publisher
SPRINGER
DOI: 10.1007/s00221-005-0061-7
Keywords
c-fos; immediate early gene; novelty; gene expression; immuno-chemistry
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Exposure to novel environments is known to induce c-fos expression in the cingulate cortex and dorsomedial striatum. This study examined the effects of 1, 3, and 7 days of exposure to sequential exposure to three novel environments. It was hypothesized that the ability of novel environment shuttling (NES) would induce c-fos expression as indicated by cells displaying FOS-like immunoreactivity (FLI) in the striatum and cingulate cortex which would decrease with repeated exposure. NES elicited FLI in both the cingulate cortex and striatum when compared to home-cage controls and this effect was attenuated with repeated exposure. Behavioral measures of activity decreased with repeated exposure suggesting that the decrease in FLI may be due to either a reduction in motor activity or increasing familiarity with the environments.
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