Journal
JOURNAL OF COMPARATIVE PATHOLOGY
Volume 133, Issue 4, Pages 253-260Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2005.05.004
Keywords
alimentary lymphoma; b-cell lymphoma; cat; feline IBD; lymphoma; T-cell lymphoma; tumour
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Intestinal tissue samples were examined from 32 cats in which a histopathological diagnosis of alimentary lymphoma or multicentric lymphoma affecting the gastrointestinal tract had been made. These samples were re-evaluated histopathologically and serial sections were examined immunohistochemically with antisera specific for the lymphoid markers CD3, CD79a and BLA-36 and for class II molecules of the major histocompatability complex. The cats ranged in age from 4-16 years (median 10.5 years). The main presenting clinical signs were vomiting, diarrhoea and weight loss. The majority of alimentary lymphomas 9 1 were of the B-cell type (n = 15), whereas cases of T-cell lymphoma were fewer in number (n = 8). Four cats had lymphoma of a mixed T-and B-cell phenotype. In five of the cats, immunohistochemistry, suggested an inflammatory process, in contradiction to the original histopathological diagnosis of lymphoma. Immunolabelling would appear to be a useful adjunct to histopathology in classifying cases of feline alimentary lymphoma, and may help in distinguishing lymphoma from severe intestinal inflammation. (c) 2005 Elsevier Ltd. All rights reserved.
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