Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 9, Issue 6, Pages 787-791Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op0501500
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The Grignard exchange reaction of ethylmagnesium bromide (EtMgBr) and bromopentafluorobenzene (BPFB) to give pentafluorophenylmagnesium bromide (PFPMgBr) was carried out using small- and medium-scale microflow systems consisting of a micromixer and a microheat exchanger. The results indicate that the microflow systems are quite effective. On the basis of the data obtained, a pilot that involves the Toray Hi-mixer connected to a shell and tube microheat exchanger was constructed. Continuous operation for 24 h was accomplished without any problem to obtain pentafluorobenzene (PFB) after protonation (92% yield).
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