Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 9, Pages 5624-5628Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.9.5624
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- NIAID NIH HHS [AI 52351] Funding Source: Medline
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IFN-gamma drives CD4(+) T cell differentiation toward the Th1 phenotype (T(h)1) and suppresses T(h)2 development. Current. evidence indicates that IFN-gamma inhibits T cell proliferation and decreases T cell survival In contrast to the above, we show here that antiviral CD4+ T cell generation after infection is reduced in the absence of IFN-gamma signals. The deficient expansion of cells was not due to perturbations in T cell sensitivity to peptide or to altered migratory patterns through nonlymphoid tissues. Instead, IFN-gamma enhanced early antiviral CD4 responses largely through direct signals into these cells. Our data challenge prevailing dogma and have implications for how the sizes of the CD8(+) and CD4(+) T cell responses are established.
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