Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 11, Pages 872-884Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1744
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Mammalian development requires the specification of over 200 cell types from a single totipotent cell. Investigation of the regulatory networks that are responsible for pluripotency in embryo-derived stem cells is fundamental to understanding mammalian development and realizing therapeutic potential. Extracellular signals and second messengers modulate cell-autonomous regulators such as OCT4, SOX2 and Nanog in a combinatorial complexity. Knowledge of this circuitry might reveal how to achieve phenotypic changes without the genetic manipulation of Oct4, Nanog and other toti/pluripotency-associated genes.
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