Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 12, Issue 11, Pages 1015-1016Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb998
Keywords
-
Funding
- NCRR NIH HHS [RR02250] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 60635] Funding Source: Medline
- NINDS NIH HHS [R01 NS 43258] Funding Source: Medline
Ask authors/readers for more resources
Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available