Journal
HISTOCHEMISTRY AND CELL BIOLOGY
Volume 124, Issue 5, Pages 379-390Publisher
SPRINGER
DOI: 10.1007/s00418-005-0043-7
Keywords
P2Y(2) receptor; enteric nervous system; guinea pig
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Funding
- Wellcome Trust Funding Source: Medline
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The distribution of P2Y(2) receptor-immunoreactive (ir) neurons and fibers and coexistence of P2Y(2) with P2X(2) and P2X(3) receptors, neuropeptide Y (NPY), calretinin (CR), calbindin (CB) and nitric oxide synthase (NOS) was investigated with immunostaining methods. The results showed that P2Y(2)-ir neurons and fibers were distributed widely in myenteric and submucous plexuses of the guinea pig stomach corpus, jejunum, ileum and colon. The typical morphology of P2Y(2)-ir neurons was a long process with strong positive staining on the same side of the cell body. The P2Y(2)-ir neurons could be Dogiel type 1. About 40-60% P2X(3)-ir neurons were immunoreactive for P2Y(2) in the myenteric plexus and all the P2X(3)-ir neurons expressed the P2Y(2) receptor in the submucosal plexus; almost all the NPY-ir neurons and the majority of CR-ir neurons were also immunoreactive for P2Y(2), especially in the myenteric plexus of the small intestine; no P2Y(2)-ir neurons were immunoreactive for P2X(2) receptors, CB and NOS. It is shown for the first time that S type/Dogiel type 1 neurons with fast P2X and slow P2Y receptor-mediated depolarizations could be those neurons expressing both P2Y(2)-ir and P2X(3)-ir and that they are widely distributed in myenteric and submucosal plexuses of guinea pig gut.
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